In 2021, the U.S. Department of Agriculture’s National Animal Health Monitoring System, in collaboration with the USDA’s National Agricultural Statistics Service, conducted its third national study of U.S. small-enterprise swine operations. Approximately 5,000 swine operations from 38 states, accounting for about 95% of U.S. swine operations with fewer than 1,000 pigs, were asked to participate. Small-enterprise swine production is a growing sector of the U.S. swine industry due to its role as a primary supplier of many niche-market products.